Associate Professor Hai-Guang Liu

Complex Systems

Office Location
Room A305

B.Sc. (first class honor) Physics, Hong Kong Baptist University (2003)

Ph.D. Applied Science, University of California, Davis (2009)

Professional Employment

Dr. Haiguang Liu started college in Tsinghua University and received Bachelor of Science with first class honor in 2003. He got Ph.D. degree in 2009, from in University of California, Davis. Dr. Liu worked in Lawrence Berkeley National Laboratories (2009-2011) and Arizona State University (2011-2014) as a postdoctoral fellow. Since 2011, Dr. Liu has been an associate member of CSRC, and joined CSRC as a tenure track assistant professor in 2014. He is currently a visiting scientist of Arizona State University.

Research Interests

Our Research focus is on computational modeling of biomolecules, assembly, and machinaries, from snapshots obtained using conventional structural biology methods to molecular movies using simulations and time-resolved technologies. Currently, we focus on incorporating three types of experimental data into modeling, namely, the X-ray diffraction especially using the newly emerged X-ray Free Electron Laser, the cryo electron microscopy (cryoEM), and the single molecule fluorescence experiments. Our long-term goal is to develop a computational platform to facilitate the integration of structural information obtained from different experiments.

We also develop algorithms and software for information analysis from ‘big data’.

Representative Publications
1.  Kupitz, C. et al. Serial time-resolved crystallography of photosystem II using a femtosecond X-ray laser. Nature,513, 261(2014).
2.  Liu, H., Hexemer, A. & Zwart, P. H. The Small Angle Scattering ToolBox (SASTBX): An open source software for biomolecular small angle scattering. J. Appl. Crystallogr.45, 587–593 (2012).
3.  Liu, H., Poon, B. K., Saldin, D. K., Spence, J. C. H. & Zwart, P. H. Three-dimensional single-particle imaging using angular correlations from X-ray laser data. Acta Crystallogr. Sect. A Found. Crystallogr.69, 365–373 (2013).
4.  Liu, H. & Spence, J. C. H. The indexing ambiguity in serial femtosecond crystallography (SFX) resolved using an expectation maximization algorithm. IUCrJ1, 305 (2014).
5.  Liu, H., Zatsepin, N. A. & Spence, J. C. H. Ab-initio phasing using nanocrystal shape transforms with incomplete unit cells. IUCrJ1, 19–27 (2014).
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