Ultrahigh Spatiotemporal Resolution Optical Measurement and Microfluidics Applications
Prof. Gui-Ren Wang
Biomedical Engineering Program and Department of Mechanical Engineering, University of South Carolin

As a multidisciplinary and new field, micro/nanofluidics based lab-on-a-chip is attracting interests of many scientists and engineers from various areas. In order to develop novel microfluidic device, some fundamental issues (physical, chemical and biological properties) in interfacial flows have to be addressed and measured with nanoscale resolution. However, current measuring techniques have mostly spatial resolution on the order of a few micrometers using micro- or nanoparticles as tracers, whose velocity in many cases is unfortunately different from that of fluids.  Here we introduce a novel small and neutral molecules as the tracer, i.e. Laser Induced Fluorescence Photobleaching Anemometer (LIFPA), to measure flow velocity in micro- and nanochannels. We also developed a far field optical nanoscopy based on stimulated emission depletion (STED) with femto lasers. Inteagrated with STED, LIFPA has potential to measure interfacial flows, such as slip flow with unprecedented high spatial (~ 70 nm) and temporal resolution (5 µs) resolution in micro/nanofluidics. Femto laser can enhance the performance of LIFPA by increasing its dynamic range. We also use STED for nanofabrication of nanostructures to overcome diffraction limit in photolithography. Finally we also introduce our microfliudic cell sorter based on dielectrophoresis for cancer cell separation.


About the Speaker

Dr. Wang with a multidisciplinary background, is currently an Associate Professor in the Department of Mechanical Engineering and Biomedical Engineering Program, University of South Carolina, Columbia, South Carolina, USA. Dr. Wang received his PhD. from Technische Universität Berlin. He was a postdoctoral research fellow in Stanford University. After working in industrial for about seven years, he came back to academia. Dr. Wang received Career Award from National Science Foundation (NSF), North American Mixing Forum and Rising Star from the University of South Carolina. As the Principal Investigator, he received the grant from NSF for Major Research Instrumentation. Currently his research interests include nano/microfluidics and biochip, super-resolution far field nanoscopy based on Stimulated Emission Depletion (STED), early cancer detection, nano/microfabrication, fluorescence detection, turbulent and mixing, etc.


2016-06-23 3:00 PM
Room: A303 Meeting Room
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