A robust method for designing multistable systems by embedding bistable subsystems
Prof. Tianhai Tian

In this talk we discuss a robust method to develop multistable mathematical models by embedding bistable models together. Using the GATA1-GATA2-PU.1 module in hematopoiesis as the test system, we discuss a tristable model based on two bistable models without any high cooperative coefficients, and then modify the tristable model based on experimentally determined mechanisms. The modified model successfully realises four stable steady states and accurately reflects a recent experimental observation showing four transcriptional states. The proposed method is a general approach to develop mathematical models for realising multistability and heterogeneity in complex systems.

About the Speaker


2022-10-24 1:00 PM
Room: Tencent Meeting
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